Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women-Reference-Cited by-同舟云学术

Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women

Published:2020-09-22 Issue:20 Volume:63 Page:11854-11881
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Panknin Olaf¹^ORCID,Wagenfeld Andrea¹,Bone Wilhelm¹,Bender Eckhard²,Nowak-Reppel Katrin¹,Fernández-Montalván Amaury E.¹^ORCID,Nubbemeyer Reinhard¹,Bäurle Stefan¹^ORCID,Ring Sven¹,Schmees Norbert¹,Prien Olaf¹,Schäfer Martina¹,Friedrich Christian¹,Zollner Thomas M.¹,Steinmeyer Andreas¹,Mueller Thomas²,Langer Gernot¹

Affiliation:

1. Research & Development, Pharmaceuticals, Bayer AG, Müllerstrasse 170, 13342 Berlin, Germany

2. Research & Development, Pharmaceuticals, Bayer AG, Aprather Weg 18a, 42113 Wuppertal, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01076

Reference74 articles.

1. Uterine fibroids

2. Epidemiology of uterine fibroids: a systematic review

3. Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?

4. The Epidemiology and Genetics of Uterine Leiomyoma

5. Hormones and pathogenesis of uterine fibroids

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