Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Author:

Rai Ganesha1ORCID,Urban Daniel J.1,Mott Bryan T.1,Hu Xin1,Yang Shyh-Ming1ORCID,Benavides Gloria A.2,Johnson Michelle S.2,Squadrito Giuseppe L.2,Brimacombe Kyle R.1,Lee Tobie D.1,Cheff Dorian M.1,Zhu Hu1,Henderson Mark J.1ORCID,Pohida Katherine1,Sulikowski Gary A.3ORCID,Dranow David M.4,Kabir Md1,Shah Pranav1,Padilha Elias1,Tao Dingyin1ORCID,Fang Yuhong1,Christov Plamen P.3,Kim Kwangho3,Jana Somnath3,Muttil Pavan5ORCID,Anderson Tamara5,Kunda Nitesh K.5ORCID,Hathaway Helen J.5,Kusewitt Donna F.6,Oshima Nobu7,Cherukuri Murali7,Davies Douglas R.4,Norenberg Jeffrey P.5,Sklar Larry A.6,Moore William J.8,Dang Chi V.910,Stott Gordon M.8,Neckers Leonard7,Flint Andrew J.8,Darley-Usmar Victor M.2,Simeonov Anton1,Waterson Alex G.3,Jadhav Ajit1,Hall Matthew D.1ORCID,Maloney David J.1ORCID

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States

3. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

4. Beryllium Discovery Corp., 7869 Day Road West, Bainbridge Island, Washington 98110, United States

5. College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States

6. Dept of Pathology, University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, United States

7. Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

8. NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States

9. Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

10. Ludwig Institute for Cancer Research, New York, New York 10017, United States

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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