CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1-Reference-Cited by-同舟云学术

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CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1

Published:2020-07-31 Issue:17 Volume:63 Page:9965-9976
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meng Xiaoli¹^ORCID,Waddington James C.¹,Tailor Arun¹,Lister Adam¹,Hamlett Jane¹,Berry Neil²^ORCID,Park B. Kevin¹,Sporn Michael B.³

Affiliation:

1. MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, U.K.

2. Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.

3. Molecular and Systems Biology, Dartmouth Medical School, Lebanon, New Hampshire 03756, United States

Funder

Medical Research Council

Triterpenoid Therapeutics, Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01088

Reference46 articles.

1. Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease

2. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

3. The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

4. Complete Protection against Aflatoxin B1-Induced Liver Cancer with a Triterpenoid: DNA Adduct Dosimetry, Molecular Signature, and Genotoxicity Threshold

5. Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study

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1. The role of Nrf2 signaling pathways in nerve damage repair;Toxicology Research;2024-05-01

2. Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway;International Immunopharmacology;2024-01

3. Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model;International Journal of Molecular Sciences;2023-08-28

4. Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly;Free Radical Biology and Medicine;2023-08

5. Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors;Journal of Medicinal Chemistry;2023-07-13

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