Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2-Reference-Cited by-同舟云学术

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Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2

Published:2021-04-27 Issue:9 Volume:64 Page:5447-5469
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Roy Michael J.¹²^ORCID,Vom Amelia¹²,Okamoto Toru¹²,Smith Brian J.¹²^ORCID,Birkinshaw Richard W.¹²,Yang Hong¹²,Abdo Houda¹²,White Christine. A.¹²,Segal David¹,Huang David C. S.¹²,Baell Jonathan B.¹²^ORCID,Colman Peter M.¹²,Czabotar Peter E.¹²,Lessene Guillaume¹²³^ORCID

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia

2. Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia

3. Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3050, Australia

Funder

National Health and Medical Research Council

Australian Cancer Research Foundation

Australian Research Council

Australian Government

State Government of Victoria

Leukemia and Lymphoma Society

Cancer Council Victoria

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01771

Reference75 articles.

1. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

2. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy

3. BCL-2 family antagonists for cancer therapy

4. From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

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4. Structural insights into apoptotic regulation of human Bfk as a novel Bcl-2 family member;Computational and Structural Biotechnology Journal;2022

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