Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2-Reference-Cited by-同舟云学术

Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2

Published:2020-11-16 Issue:22 Volume:63 Page:13733-13744
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Ziqian¹,Song Ting¹,Guo Zongwei²,Cao Keke²,Chen Chao³,Feng Yingang³^ORCID,Wang Hang⁴,Yin Fangkui¹,Zhou Sheng¹,Dai Jian¹,Zhang Zhichao¹^ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China

2. School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, China

3. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China

4. School of Innovation and Entrepreneurship, Dalian University of Technology, Dalian, Liaoning 116024, China

Funder

Ministry of Education of the People's Republic of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01290

Reference44 articles.

1. Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

2. The origins of protein phosphorylation

3. Phosphorylation in Protein-Protein Binding: Effect on Stability and Function

4. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

5. Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

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