Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities-Reference-Cited by-同舟云学术

Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities

Published:2020-09-03 Issue:19 Volume:63 Page:11054-11084
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cioffi Christopher L.¹^ORCID,Muthuraman Parthasarathy¹,Raja Arun¹,Varadi Andras²,Racz Boglarka²,Petrukhin Konstantin²

Affiliation:

1. Departments of Basic and Clinical Sciences and Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, New York 12208, United States

2. Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, United States

Funder

National Eye Institute

Columbia University

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00996

Reference119 articles.