Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate

Author:

Zhou Yu12ORCID,Fu Yan3,Yin Wanchao3,Li Jian14,Wang Wei3,Bai Fang5ORCID,Xu Shengtao1,Gong Qi3,Peng Tao1,Hong Yu1,Zhang Dong1,Zhang Dan1,Liu Qiufeng3,Xu Yechun32ORCID,Xu H. Eric32,Zhang Haiyan32ORCID,Jiang Hualiang12,Liu Hong12ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People’s Republic of China

2. School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People’s Republic of China

3. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China

4. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing 210023, People’s Republic of China

5. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People’s Republic of China

Funder

Ministry of Science and Technology of the People's Republic of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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