Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery-Reference-Cited by-同舟云学术

Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery

Published:2021-05-18 Issue:10 Volume:64 Page:6706-6719
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kryštůfek Robin¹²^ORCID,Šácha Pavel¹³,Starková Jana¹,Brynda Jiří¹⁴,Hradilek Martin¹,Tloušt’ová Eva¹,Grzymska Justyna⁵,Rut Wioletta⁵,Boucher Michael J.⁶,Drąg Marcin⁵,Majer Pavel¹,Hájek Miroslav¹,Řezáčová Pavlína¹⁴,Madhani Hiten D.⁶⁷,Craik Charles S.⁸^ORCID,Konvalinka Jan¹³^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic

2. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles UniversityHlavova 8, Prague 2 12843, Czech Republic

3. Department of Biochemistry, Faculty of Science, Charles UniversityHlavova 8, Prague 2 12843, Czech Republic

4. Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, Prague 4 14220, Czech Republic

5. Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland

6. Department of Biochemistry & Biophysics, University of California, San Francisco, UCSF Genentech Hall, 600 16th St Rm N374, San Francisco, California 94158, United States

7. Chan-Zuckerberg Biohub, 499 Illinois Street, San Francisco, California 94158, United States

8. Department of Pharmaceutical Chemistry, University of California San Francisco, UCSF Genentech Hall, 600 16th St Rm S512, San Francisco, California 94158, United States

Funder

European Regional Development Fund

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02177

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2. HIV-associated cryptococcal meningitis