Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via 15N Direct Detection Nuclear Magnetic Resonance-Reference-Cited by-同舟云学术

Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via 15N Direct Detection Nuclear Magnetic Resonance

Published:2020-05-06 Issue:10 Volume:63 Page:5360-5366
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tokunaga Yuji¹²,Takeuchi Koh¹,Okude Junya³,Ori Kazutomo³,Torizawa Takuya³,Shimada Ichio¹⁴^ORCID

Affiliation:

1. Molecular Profiling Research Center for Drug Discovery and Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan

2. Research and Development Department, Japan Biological Informatics Consortium, 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan

3. Chugai Pharmaceutical Company, Ltd., 200 Kajiwara, Kamakura City, Kanagawa 247-8530, Japan

4. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00231

Reference37 articles.

1. Glycan analysis of therapeutic glycoproteins

2. Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near‐ and far‐UV CD for protein higher order structural analysis

3. High-Throughput Thermal Stability Analysis of a Monoclonal Antibody by Attenuated Total Reflection FT-IR Spectroscopic Imaging

4. Use of Raman and Raman optical activity for the structural characterization of a therapeutic monoclonal antibody formulation subjected to heat stress

5. Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

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