Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

Author:

Cockerill G. Stuart1ORCID,Angell Richard M.2,Bedernjak Alexandre1,Chuckowree Irina2,Fraser Ian1,Gascon-Simorte Jose2,Gilman Morgan S. A.3,Good James A. D.1,Harland Rachel1,Johnson Sara M.4,Ludes-Meyers John H3,Littler Edward1,Lumley James1,Lunn Graham2,Mathews Neil1,McLellan Jason S.3,Paradowski Michael5,Peeples Mark E.4,Scott Claire1,Tait Dereck1,Taylor Geraldine6,Thom Michelle6,Thomas Elaine1,Villalonga Barber Carol2,Ward Simon E.5ORCID,Watterson Daniel7,Williams Gareth2,Young Paul7,Powell Kenneth1

Affiliation:

1. Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K.

2. Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K.

3. Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States

4. Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43205, United States

5. Medicines Discovery Institute, Cardiff University, Cardiff, Wales CF10 3AT, U.K.

6. The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, U.K.

7. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia

Funder

National Institute of Allergy and Infectious Diseases

Pfizer

Cystic Fibrosis Foundation

Wellcome Trust

Janssen Pharmaceuticals

Reviral Ltd

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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