Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases-Reference-Cited by-同舟云学术

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases

Published:2021-02-08 Issue:4 Volume:64 Page:2139-2150
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mallart Sergio¹^ORCID,Ingenito Raffaele²^ORCID,Bianchi Elisabetta²^ORCID,Bresciani Alberto³^ORCID,Esposito Simone⁴^ORCID,Gallo Mariana⁵,Magotti Paola²,Monteagudo Edith⁴,Orsatti Laura⁴^ORCID,Roversi Daniela²,Santoprete Alessia²,Tucci Federica²,Veneziano Maria⁴,Bartsch Régine¹,Boehm Claudius⁶,Brasseur Denis¹,Bruneau Patricia¹,Corbier Alain⁷,Froissant Jacques¹,Gauzy-Lazo Laurence¹^ORCID,Gervat Vincent¹,Marguet Frank¹^ORCID,Menguy Isabelle¹,Minoletti Claire¹^ORCID,Nicolas Marie-Françoise⁸,Pasquier Olivier⁹,Poirier Bruno⁷^ORCID,Raux Alexandre¹,Riva Laurence⁷,Janiak Philip⁷^ORCID,Strobel Hartmut²,Duclos Olivier¹,Illiano Stephane⁷^ORCID

Affiliation:

1. Integrated Drug Discovery, Sanofi R&D, 1 rue Pierre Brossolette, Chilly Mazarin 91385, France

2. Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina Km 30 600, Pomezia, Rome 00 071, Italy

3. Department of Translational Biology, IRBM Spa, Via Pontina Km 30 600, Pomezia, Rome 00 071, Italy

4. DMPK, IRBM Spa, Via Pontina Km 30 600, Pomezia, Rome 00 071, Italy

5. Structural Biology, IRBM Spa, Via Pontina Km 30 600, Pomezia, Rome 00 071, Italy

6. Industrial Affairs, iCMC, Sanofi-Aventis R&D, Industriepark Höchst, Frankfurt 65926, Germany

7. Cardio-Vascular and metabolism, Sanofi R&D, 1 rue Pierre Brossolette, Chilly Mazarin 91385, France

8. Preclinical Development Sciences, Sanofi R&D, 13 quai Jules Guesde, Vitry sur Seine 94400, France

9. DMPK France, Sanofi R&D, 3 digue d’Alfortville, Alfortville 94140, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01533

Reference38 articles.

1. International Union of Basic and Clinical Pharmacology. XCV. Recent Advances in the Understanding of the Pharmacology and Biological Roles of Relaxin Family Peptide Receptors 1–4, the Receptors for Relaxin Family Peptides

2. The actions of relaxin on the human cardiovascular system

3. Effects of Relaxin on Arterial Dilation, Remodeling, and Mechanical Properties

4. Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats

5. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease

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