Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer’s Disease-Reference-Cited by-同舟云学术

Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer’s Disease

Published:2020-09-22 Issue:20 Volume:63 Page:11663-11690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de Matos Ana M.¹,Blázquez-Sánchez M. Teresa¹,Bento-Oliveira Andreia¹,de Almeida Rodrigo F. M.¹,Nunes Rafael¹²^ORCID,Lopes Pedro E. M.²,Machuqueiro Miguel²,Cristóvão Joana S.²,Gomes Cláudio M.²^ORCID,Souza Cleide S.³,El Idrissi Imane G.⁴,Colabufo Nicola A.⁴^ORCID,Diniz Ana⁵,Marcelo Filipa⁵,Oliveira M. Conceição⁶,López Óscar⁷,Fernandez-Bolaños José G.⁷^ORCID,Dätwyler Philipp⁸,Ernst Beat⁸^ORCID,Ning Ke⁹,Garwood Claire⁹,Chen Beining³,Rauter Amélia P.¹^ORCID

Affiliation:

1. Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal

2. Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal

3. Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, United Kingdom

4. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “A. Moro”, Via Orabona, 4, 70125 Bari, Italy

5. UCIBIO, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica 2829-516, Portugal

6. Mass Spectrometry Facility at CQE, Insituto Superior Técnico, Av. Rovisco Pais, Lisboa 1049-001, Portugal

7. Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, Sevilla E-41071, Spain

8. Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel CH-4056, Switzerland

9. Department of Neuroscience, Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield S10 2HQ, United Kingdom

Funder

FP7 People: Marie-Curie Actions

Junta de Andaluc?a

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00841

Reference87 articles.

1. Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential

2. Targeting Fyn Kinase in Alzheimer’s Disease

3. Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

4. Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model

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