Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

Published:2020-12-08 Issue:24 Volume:63 Page:15821-15851
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Caputo Samantha¹²,Di Martino Simona¹²^ORCID,Cilibrasi Vincenzo¹²,Tardia Piero¹²,Mazzonna Marco¹²,Russo Debora¹³,Penna Ilaria¹³,Summa Maria¹⁴,Bertozzi Sine Mandrup¹⁴,Realini Natalia¹²,Margaroli Natasha¹²,Migliore Marco¹²,Ottonello Giuliana¹⁴,Liu Min⁵,Lansbury Peter⁵,Armirotti Andrea¹⁴^ORCID,Bertorelli Rosalia¹⁴,Ray Soumya S.⁵,Skerlj Renato⁵,Scarpelli Rita¹²^ORCID

Affiliation:

1. Fondazione Istituto Italiano di Tecnologia, Via Morego 30, I-16163 Genova, Italy

2. Drug Discovery and Development (D3)-Validation, Via Morego 30, I-16163 Genova, Italy

3. D3-Pharma Chemistry, Via Morego 30, I-16163 Genova, Italy

4. Analytical Chemistry and Translational Pharmacology, Via Morego 30, I-16163 Genova, Italy

5. Lysosomal Therapeutics Inc., 19 Blackstone Street, Cambridge, Massachusetts 02139, United States

Funder

Istituto Italiano di Tecnologia

Lysosomal Therapeutics Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01561

Reference75 articles.

1. Many Ceramides

2. Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate

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5. Lyso-glycosphingolipids: presence and consequences

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