High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues-Reference-Cited by-同舟云学术

High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues

Published:2020-11-16 Issue:22 Volume:63 Page:13656-13668
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhu Xiaopeng¹²^ORCID,Pan Si³,Xu Manyu³,Zhang Lu²,Yu Jinfang³,Yu Jinpeng¹,Wu Yong¹,Fan Yingxu⁴,Li Haonan²,Kasheverov Igor E.⁵⁶,Kudryavtsev Denis S.⁵,Tsetlin Victor I.⁵⁷,Xue Yi⁴,Zhangsun Dongting¹²,Wang Xinquan³,Luo Sulan¹²^ORCID

Affiliation:

1. Medical School, Guangxi University, Nanning 530004, China

2. Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China

3. The Ministry of Education Key Laboratory of Protein Science, School of Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, China

4. Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China

5. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow 117997, Russia

6. Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya Street 8, bld. 2, Moscow 119991, Russia

7. PhysBio of MePhi, Kashirskoe Ave. 31, Moscow 115409, Russia

Funder

Russian Science Foundation

Russian Foundation for Basic Research

National Natural Science Foundation of China

Hainan Province

Publisher

American Chemical Society (ACS)

Subject