Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay-Reference-Cited by-同舟云学术

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Published:2020-07-30 Issue:15 Volume:63 Page:8276-8295
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Knoepfel Thomas^ORCID,Nimsgern Pierre,Jacquier Sébastien,Bourrel Marjorie,Vangrevelinghe Eric,Glatthar Ralf,Behnke Dirk,Alper Phil B.¹^ORCID,Michellys Pierre-Yves¹,Deane Jonathan¹,Junt Tobias,Zipfel Géraldine,Limonta Sarah,Hawtin Stuart,Andre Cedric,Boulay Thomas,Loetscher Pius,Faller Michael,Blank Jutta,Feifel Roland,Betschart Claudia

Affiliation:

1. Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00130

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