Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

Author:

Kancharla Papireddy1ORCID,Dodean Rozalia A.2ORCID,Li Yuexin2,Pou Sovitj2,Pybus Brandon3,Melendez Victor3,Read Lisa3,Bane Charles E.3,Vesely Brian3,Kreishman-Deitrick Mara3,Black Chad3,Li Qigui3,Sciotti Richard J.3,Olmeda Raul3,Luong Thu-Lan3,Gaona Heather3,Potter Brittney3,Sousa Jason3,Marcsisin Sean3,Caridha Diana3,Xie Lisa3,Vuong Chau3,Zeng Qiang3,Zhang Jing3,Zhang Ping3,Lin Hsiuling3,Butler Kirk3,Roncal Norma3,Gaynor-Ohnstad Lacy3,Leed Susan E.3,Nolan Christina3,Ceja Frida G.4,Rasmussen Stephanie A.4,Tumwebaze Patrick K.5,Rosenthal Philip J.6,Mu Jianbing7ORCID,Bayles Brett R.48,Cooper Roland A.4,Reynolds Kevin A.1ORCID,Smilkstein Martin J.2,Riscoe Michael K.12,Kelly Jane X.12ORCID

Affiliation:

1. Department of Chemistry, Portland State University, Portland, Oregon 97201, United States

2. Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States

3. Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States

4. Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States

5. Infectious Diseases Research Collaboration, Kampala, Uganda

6. Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States

7. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, United States.

8. Global Public Health Program, Dominican University of California, San Rafael, California 94901, United States

Funder

National Institute of Allergy and Infectious Diseases

Congressionally Directed Medical Research Programs

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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