Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros-Reference-Cited by-同舟云学术

Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros

Published:2021-03-16 Issue:2 Volume:65 Page:1265-1282
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Baumann Georg¹,Meckel Tobias¹,Böhm Kevin¹,Shih Yung-Hsin¹,Dickhaut Mirco¹,Reichardt Torben¹,Pilakowski Johannes¹,Pehl Ulrich²,Schmidt Boris¹^ORCID

Affiliation:

1. Clemens Schöpf−Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, 64287 Darmstadt, Germany

2. Merck Healthcare KGaA, Biopharma R&D, Discovery and Development Technologies, 64293 Darmstadt, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02118

Reference66 articles.

1. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

2. A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.

3. “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases

4. Checking NEKs: Overcoming a Bottleneck in Human Diseases

5. Identification and Genetic Mapping of a New Polycystic Kidney Disease on Mouse Chromosome 8

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