Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia-Reference-Cited by-同舟云学术

Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia

Published:2020-03-02 Issue:6 Volume:63 Page:3370-3380
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liang Jinhao¹,Huang Yi-You²,Zhou Qian²,Gao Yuqi²,Li Zhe²,Wu Deyan²^ORCID,Yu Si¹,Guo Lei²,Chen Zhen³^ORCID,Huang Ling²^ORCID,Liang Steven H.³^ORCID,He Xixin¹,Wu Ruibo²,Luo Hai-Bin²^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China

3. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States

Funder

National Natural Science Foundation of China

Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme

Science Foundation of Guangzhou City

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00060

Reference27 articles.

1. Vascular Contributions to Cognitive Impairment and Dementia