Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template-Reference-Cited by-同舟云学术

Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

Published:2020-11-10 Issue:22 Volume:63 Page:13618-13637
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Faouzi Abdelfattah¹²,Uprety Rajendra³,Gomes Ivone⁴,Massaly Nicolas²,Keresztes Attila I.⁵,Le Rouzic Valerie³,Gupta Achla⁴,Zhang Tiffany³,Yoon Hye Jean²,Ansonoff Michael⁶,Allaoa Abdullah³,Pan Ying Xian³,Pintar John⁶,Morón Jose A.²⁷,Streicher John M.⁵^ORCID,Devi Lakshmi A.⁴^ORCID,Majumdar Susruta¹²^ORCID

Affiliation:

1. Center for Clinical Pharmacology, St Louis College of Pharmacy and Washington University, School of Medicine, St. Louis, Missouri 63110, United States

2. Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States

3. Department of Neurology and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

4. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

5. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arkansas 85724, United States

6. Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, United States

7. Department of Neuroscience and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, United States

Funder

National Cancer Institute

Office of the Secretary of Defense

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Center for Clinical Pharmacology, Washington University

St Louis College of Pharmacy

Phillipe Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00901

Reference72 articles.

1. Advances in Achieving Opioid Analgesia Without Side Effects

2. Opioid receptors: drivers to addiction?

3. Mu Opioids and Their Receptors: Evolution of a Concept

4. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

5. Structure-based discovery of opioid analgesics with reduced side effects

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