Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode-Reference-Cited by-同舟云学术

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode

Published:2016-02-17 Issue:5 Volume:59 Page:2067-2082
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sawatzky Edgar¹,Wehle Sarah¹,Kling Beata²,Wendrich Jan³,Bringmann Gerhard³,Sotriffer Christoph A.¹,Heilmann Jörg²,Decker Michael¹

Affiliation:

1. Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

2. Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany

3. Lehrstuhl für Organische Chemie I, Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

Funder

Deutsche Forschungsgemeinschaft

Studienstiftung des Deutschen Volkes

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01674

Reference87 articles.

1. Alzheimer's Disease

2. Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

3. Soluble Aβ oligomer production and toxicity

Cited by 89 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands;European Journal of Medicinal Chemistry;2024-09

2. Dehydration in Water: A Reagentless and Straightforward Synthesis of Tetrahydroquinazolines under Microwave Irradiation or by Stirring at Room Temperature, and Their Subsequent Conversion into Quinazolines in a Micellar Medium;Synthesis;2024-06-19

3. Improved Affinity: A Customized Fluorescent Probe for the Rapid Detection of Butyrylcholinesterase;Chemosensors;2024-06-05

4. The selective butyrylcholinesterase inhibitor UW‐MD‐95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease;CNS Neuroscience & Therapeutics;2024-06

5. Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases;ACS Chemical Neuroscience;2024-04-22