Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

Author:

Zha Xiaoming1,Lamba Doriano2,Zhang Lili1,Lou Yinghan1,Xu Changxu1,Kang Di1,Chen Li,Xu Yungen,Zhang Luyong1,De Simone Angela3,Samez Sarah24,Pesaresi Alessandro2,Stojan Jure5,Lopez Manuela G.6,Egea Javier6,Andrisano Vincenza3,Bartolini Manuela7

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. China

2. Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park - Basovizza, S.S. no. 14 Km 163.5, I-34149 Trieste, Italy

3. Department for Life Quality Studies, University of Bologna, Corso d’Augusto 237, I-47921 Rimini, Italy

4. Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste, Via L. Giorgieri 1, I-34127 Trieste, Italy

5. Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia

6. Instituto Teófilo Hernando, Department of Pharmacology, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 4, 28029 Madrid, Spain

7. Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy

Funder

Ministry of Education of the People's Republic of China

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Ministerio de Economia y Competitividad

UniRimini S.p.A

CIRI - Centro Interdipartimentale di Ricerca Industriale

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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