Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target-Reference-Cited by-同舟云学术

Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target

Published:2015-09-23 Issue:19 Volume:58 Page:7707-7718
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Watson Gabrielle M.,Gunzburg Menachem J.,Ambaye Nigus D.,Lucas William A. H.,Traore Daouda A.,Kulkarni Ketav,Cergol Katie M.¹,Payne Richard J.¹,Panjikar Santosh²,Pero Stephanie C.³,Perlmutter Patrick,Wilce Matthew C. J.,Wilce Jacqueline A.

Affiliation:

1. School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia

2. Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia

3. Department of Surgery and Vermont Cancer Center, University of Vermont, Burlington, Vermont 05401, United States

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00609

Reference58 articles.

1. Hallmarks of Cancer: The Next Generation

2. GRB7 is required for triple-negative breast cancer cell invasion and survival

3. GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation

4. EGF-induced Grb7 Recruits and Promotes Ras Activity Essential for the Tumorigenicity of Sk-Br3 Breast Cancer Cells

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