Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic-Reference-Cited by-同舟云学术

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Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic

Published:2016-04-06 Issue:8 Volume:59 Page:3635-3649
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pace Jennifer R.¹,DeBerardinis Albert M.¹,Sail Vibhavari¹,Tacheva-Grigorova Silvia K.²,Chan Kelly A.¹,Tran Raymond¹,Raccuia Daniel S.¹,Wechsler-Reya Robert J.²,Hadden M. Kyle¹

Affiliation:

1. Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, Connecticut 06269-3092, United States

2. Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, United States

Funder

National Cancer Institute

Research Foundation, University of Connecticut

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01718

Reference42 articles.

1. Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

2. Inhibition of Angiogenesis by the Antifungal Drug Itraconazole

3. Antifungal agents: mechanisms of action

4. The mechanisms of Hedgehog signalling and its roles in development and disease

5. Unraveling the therapeutic potential of the Hedgehog pathway in cancer

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