Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)-Reference-Cited by-同舟云学术

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Published:2015-11-17 Issue:22 Volume:58 Page:9010-9026
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Qiao Jennifer X.¹,Wang Tammy C.¹,Adam Leonard P.¹,Chen Alice Ye A.¹,Taylor David S.¹,Yang Richard Z.¹,Zhuang Shaobin¹,Sleph Paul G.¹,Li Julia P.¹,Li Danshi¹,Yin Xiaohong¹,Chang Ming¹,Chen Xue-Qing¹,Shen Hong¹,Li Jianqing¹,Smith Daniel¹,Wu Dauh-Rurng¹,Leith Leslie¹,Harikrishnan Lalgudi S.¹,Kamau Muthoni G.¹,Miller Michael M.¹,Bilder Donna¹,Rampulla Richard¹,Li Yi-Xin¹,Xu Carrie¹,Lawrence R. Michael¹,Poss Michael A.¹,Levesque Paul¹,Gordon David A.¹,Huang Christine S.¹,Finlay Heather J.¹,Wexler Ruth R.¹,Salvati Mark E.¹

Affiliation:

1. Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01363

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