Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation

Author:

Hatcher John M.1,Bahcall Magda,Choi Hwan Geun,Gao Yang2,Sim Taebo34,George Rani2,Jänne Pasi A.,Gray Nathanael S.1

Affiliation:

1. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Avenue, Longwood Center LC-2209, Boston, Massachusetts 02115, United States

2. Department of Pediatric Haematology and Oncology, Dana-Farber Cancer Institute and Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02215, United States

3. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea

4. KU-KIST Graduate School of Converging Science and Technology, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea

Funder

National Cancer Institute

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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