Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

Author:

Zou Mu-Fa,Keck Thomas M.,Kumar Vivek,Donthamsetti Prashant12,Michino Mayako,Burzynski Caitlin,Schweppe Catherine,Bonifazi Alessandro,Free R. Benjamin3,Sibley David R.3,Janowsky Aaron45,Shi Lei6,Javitch Jonathan A.12,Newman Amy Hauck

Affiliation:

1. Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York 10027, United States

2. Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States

3. Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 5625 Fishers Lane, Room 4S-04, Bethesda, Maryland 20892-9405, United States

4. Research & Development Service, Veterans Affairs Portland Health Care System, Portland, Oregon 97239, United States

5. Department of Psychiatry and Behavioral Neuroscience, School of Medicine and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, Oregon 97239, United States

6. Department of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York 10065, United States

Funder

National Institute of Neurological Disorders and Stroke

U.S. Department of Veterans Affairs

National Institute on Drug Abuse

National Institute of Mental Health

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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