Novel Series of Dihydropyridinone P2X7 Receptor Antagonists
Author:
Affiliation:
1. Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00365
Reference38 articles.
1. The human P2X7 receptor and its role in innate immunity
2. The role of the purinergic P2X7 receptor in inflammation
3. The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
4. Efficacy and Safety of CE-224,535, an Antagonist of P2X7Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate
5. Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
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