An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer

Author:

Colley Helen E.1,Muthana Munitta2,Danson Sarah J.3,Jackson Lucinda V.4,Brett Matthew L.4,Harrison Joanne4,Coole Sean F.4,Mason Daniel P.4,Jennings Luke R.1,Wong Melanie5,Tulasi Vamshi5,Norman Dennis5,Lockey Peter M.5,Williams Lynne2,Dossetter Alexander G.6,Griffen Edward J.6,Thompson Mark J.4

Affiliation:

1. School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, U.K.

2. Department of Oncology, The University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, U.K.

3. Academic Unit of Clinical Oncology and Sheffield Experimental Medicine Centre, Weston Park Hospital, Whitham Road, Sheffield S10 2SJ, U.K.

4. Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, U.K.

5. Charles River, 8−9 Spire Green Centre, Harlow, Harlow, Essex CM19 5TR, U.K.

6. MedChemica Limited, Ebenezer House, Ryecroft, Newcastle-Under-Lyme, Staffordshire ST5 2BE, U.K.

Funder

University of Sheffield

Weston Park Hospital Cancer Charity

Faculty Innovation Fund, University of Sheffield

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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