SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes

Author:

Knapinska Anna M.1,Dreymuller Daniela2,Ludwig Andreas2,Smith Lyndsay1,Golubkov Vladislav3,Sohail Anjum4,Fridman Rafael4,Giulianotti Marc56,LaVoi Travis M.5,Houghten Richard A.5,Fields Gregg B.17,Minond Dmitriy5

Affiliation:

1. Florida Atlantic University, 5353 Parkside Drive, Jupiter, Florida 33458, United States

2. Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany

3. Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States

4. Wayne State University, 8200 Scott Hall, 540 East Canfield Avenue, Detroit, Michigan 48201, United States

5. Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States

6. Department of Chemistry, Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida 33612, United States

7. The Scripps Research Institute/Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, United States

Funder

Lawton Chiles Endowment Fund

National Institute on Drug Abuse

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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