Structure–Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells-Reference-Cited by-同舟云学术

Structure–Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells

Published:2016-04-05 Issue:7 Volume:59 Page:3063-3078
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cherian Joseph¹,Nacro Kassoum¹,Poh Zhi Ying¹,Guo Samantha¹,Jeyaraj Duraiswamy A.¹,Wong Yun Xuan¹,Ho Melvyn¹,Yang Hai Yan¹,Joy Joma Kanikadu¹,Kwek Zekui Perlyn¹,Liu Boping¹,Wee John Liang Kuan¹,Ong Esther HQ¹,Choong Meng Ling¹,Poulsen Anders¹,Lee May Ann¹,Pendharkar Vishal¹,Ding Li Jun¹,Manoharan Vithya¹,Chew Yun Shan¹,Sangthongpitag Kanda¹,Lim Sharon²,Ong S. Tiong²,Hill Jeffrey¹,Keller Thomas H.¹

Affiliation:

1. Experimental Therapeutics Centre, 13 Biopolis Way, Nanos, Singapore 138669

2. Duke-National University of Singapore (NUS) Graduate Medical School, 8 College Road, Singapore, Singapore 169857

Funder

Agency for Science, Technology and Research

National Medical Research Council

Joint Council Office, Agency for Science, Technology and Research

Biomedical Sciences Institutes

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01712

Reference35 articles.

1. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

2. The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells

3. First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines

4. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

5. Phosphorylated Mnk1 and eIF4E Are Associated with Lymph Node Metastasis and Poor Prognosis of Nasopharyngeal Carcinoma

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