Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate-Reference-Cited by-同舟云学术

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate

Published:2015-07-08 Issue:14 Volume:58 Page:5620-5636
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Letavic Michael A.¹,Bonaventure Pascal¹,Carruthers Nicholas I.¹,Dugovic Christine¹,Koudriakova Tatiana¹,Lord Brian¹,Lovenberg Timothy W.¹,Ly Kiev S.¹,Mani Neelakandha S.¹,Nepomuceno Diane¹,Pippel Daniel J.¹,Rizzolio Michele¹,Shelton Jonathan E.¹,Shah Chandra R.¹,Shireman Brock T.¹,Young Lana K.¹,Yun Sujin¹

Affiliation:

1. Janssen Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00742

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