Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor-Reference-Cited by-同舟云学术

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Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor

Published:2015-12-16 Issue:24 Volume:58 Page:9773-9778
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carotenuto Alfonso¹,Merlino Francesco¹,Cai Minying²,Brancaccio Diego¹,Yousif Ali Munaim¹,Novellino Ettore¹,Hruby Victor J.²,Grieco Paolo¹³

Affiliation:

1. Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano, 49, 80131, Naples, Italy

2. Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States

3. CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, 80134, Naples, Italy

Funder

U.S. Public Health Service

National Institutes of Health

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01285

Reference31 articles.

1. Studies on the Physiological Functions of the Melanocortin System

2. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity

3. Major pharmacological distinction of the ACTH receptor from other melanocortin receptors

4. Structures of the Agouti Signaling Protein

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1. Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study;Frontiers in Pharmacology;2024-03-25

2. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH₂ Lead to Potent and Selective Agonists at hMC1R and hMC4R;Journal of Medicinal Chemistry;2023-05-03

3. Demonstration of a Common DPhe⁷ to DNal(2′)⁷ Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides;Journal of Medicinal Chemistry;2022-04-11

4. Incorporating NOE-Derived Distances in Conformer Generation of Cyclic Peptides with Distance Geometry;Journal of Chemical Information and Modeling;2022-01-14

5. Demonstration of a common DPhe⁷ to DNal(2’)⁷ peptide ligand antagonist switch for the melanocortin-3 and melanocortin-4 receptors identifies systematic mischaracterization of the pharmacological properties of melanocortin peptides;2022-01-03

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