Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders-Reference-Cited by-同舟云学术

Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders

Published:2015-11-13 Issue:22 Volume:58 Page:8920-8937
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Furlotti Guido¹,Alisi Maria Alessandra¹,Cazzolla Nicola¹,Dragone Patrizia¹,Durando Lucia¹,Magarò Gabriele¹,Mancini Francesca¹,Mangano Giorgina¹,Ombrato Rosella¹,Vitiello Marco¹,Armirotti Andrea²,Capurro Valeria²,Lanfranco Massimiliano²,Ottonello Giuliana²,Summa Maria²,Reggiani Angelo²

Affiliation:

1. Angelini S.p.A., Angelini Research Center, P.le della Stazione s.n.c., Santa Palomba-Pomezia, 00071 Rome, Italy

2. Drug Discovery and Development Department, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01208

Reference45 articles.

1. Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative

2. Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling