Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

Author:

Medellin Derek C.1,Zhou Qiong2,Scott Robert1,Hill R. Matthew1,Frail Sarah K.3,Dasari Ramesh1,Ontiveros Steven J.4,Pelly Stephen C.5,van Otterlo Willem A. L.5,Betancourt Tania16,Shuster Charles B.4,Hamel Ernest7,Bai Ruoli7,LaBarbera Daniel V.2,Rogelj Snezna3,Frolova Liliya V.3,Kornienko Alexander1

Affiliation:

1. Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States

2. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States

3. Departments of Chemistry and Biology, New Mexico Tech, Socorro, New Mexico 87801, United States

4. Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003, United States

5. Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, Western Cape, South Africa

6. Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, Texas 78666, United States

7. Screening Technologies Branch, Developmental Therapeutics Program, National Cancer Institute, Frederick National Laboratory of Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States

Funder

Division of Chemistry

National Cancer Institute

Welch Foundation

Texas Emerging Technology Fund

National Institute of Child Health and Human Development

U.S. Department of Defense

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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