Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride-Reference-Cited by-同舟云学术

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

Published:2015-03-31 Issue:7 Volume:58 Page:3172-3187
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rochais Christophe¹,Lecoutey Cédric¹,Gaven Florence²³⁴,Giannoni Patrizia²³⁴,Hamidouche Katia⁵,Hedou Damien¹,Dubost Emmanuelle¹,Genest David¹,Yahiaoui Samir¹,Freret Thomas⁵,Bouet Valentine⁵,Dauphin François⁵,Sopkova de Oliveira Santos Jana¹,Ballandonne Céline¹,Corvaisier Sophie¹⁵,Malzert-Fréon Aurélie¹,Legay Remi¹,Boulouard Michel⁵,Claeysen Sylvie²³⁴,Dallemagne Patrick¹

Affiliation:

1. UNICAEN, CERMN (Centre d’Etudes et de Recherche sur le Médicament de Normandie), F-14032 Caen, France

2. CNRS, UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France

3. Inserm, U1191, F-34000 Montpellier, France

4. Université de Montpellier, UMR-5203, F-34000 Montpellier, France

5. UNICAEN, GMPc5 (Groupe Mémoire et Plasticité comportementale), F-14032 Caen, France

Funder

Agence Nationale de la Recherche

Conseil Régional de Basse-Normandie

Ligue Européenne Contre la Maladie d'Alzheimer

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00115

Reference89 articles.

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5. Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

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