Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy-Reference-Cited by-同舟云学术

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Published:2015-08-26 Issue:17 Volume:58 Page:6875-6898
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Papeo Gianluca¹,Posteri Helena¹,Borghi Daniela¹,Busel Alina A.²,Caprera Francesco¹,Casale Elena¹,Ciomei Marina¹,Cirla Alessandra¹,Corti Emiliana¹,D’Anello Matteo¹,Fasolini Marina¹,Forte Barbara¹,Galvani Arturo¹,Isacchi Antonella¹,Khvat Alexander²,Krasavin Mikhail Y.²,Lupi Rosita¹,Orsini Paolo¹,Perego Rita¹,Pesenti Enrico¹,Pezzetta Daniele³,Rainoldi Sonia¹,Riccardi-Sirtori Federico¹,Scolaro Alessandra¹,Sola Francesco¹,Zuccotto Fabio¹,Felder Eduard R.¹,Donati Daniele¹,Montagnoli Alessia¹

Affiliation:

1. Oncology, Nerviano Medical Sciences Srl, Viale Pasteur 10, 20014 Nerviano, Milan, Italy

2. Chemical Diversity Research Institute, Rabochaya St. 2 Khimki, Moscow Region 114401, Russia

3. Accelera Srl, Viale Pasteur 10, 20014 Nerviano, Milan, Italy

Funder

Nerviano Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00680