Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies-Reference-Cited by-同舟云学术

Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Published:2015-10-27 Issue:21 Volume:58 Page:8373-8386
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Burger Matthew T.,Nishiguchi Gisele,Han Wooseok,Lan Jiong,Simmons Robert,Atallah Gordana,Ding Yu,Tamez Victoriano,Zhang Yanchen,Mathur Michelle,Muller Kristine,Bellamacina Cornelia,Lindvall Mika K.,Zang Richard,Huh Kay,Feucht Paul,Zavorotinskaya Tatiana,Dai Yumin,Basham Steve,Chan Julie,Ginn Elaine,Aycinena Alex,Holash Jocelyn,Castillo Joseph,Langowski John L.,Wang Yingyun,Chen Min Y.,Lambert Amy,Fritsch Christine¹,Kauffmann Audry¹,Pfister Estelle¹,Vanasse K. Gary²,Garcia Pablo D.

Affiliation:

1. Oncology Research, Novartis Institutes for Biomedical Research, CH-4056, Basel, Switzerland

2. Translational Clinical Oncology, Novartis Institutes for Biomedical Research, 220 Massachusetts Avenue, Cambridge Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01275

Reference27 articles.

1. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

2. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

3. Cloning and characterization of the human PIM-1 gene: A putative oncogene related to the protein kinases

4. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

5. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

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