Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

Author:

Brindisi Margherita1,Maramai Samuele1,Gemma Sandra1,Brogi Simone1,Grillo Alessandro1,Di Cesare Mannelli Lorenzo2,Gabellieri Emanuele1,Lamponi Stefania1,Saponara Simona3,Gorelli Beatrice3,Tedesco Daniele4,Bonfiglio Tommaso5,Landry Christophe6,Jung Kwang-Mook7,Armirotti Andrea8,Luongo Livio9,Ligresti Alessia10,Piscitelli Fabiana10,Bertucci Carlo4,Dehouck Marie-Pierre6,Campiani Giuseppe1,Maione Sabatino9,Ghelardini Carla2,Pittaluga Anna511,Piomelli Daniele7,Di Marzo Vincenzo10,Butini Stefania1

Affiliation:

1. European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

2. Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Firenze, V.le G. Pieraccini 6, 50139 Firenze, Italy

3. Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

4. Department of Pharmacy and Biotechnology Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

5. Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, Genova, 16148, Italy

6. Laboratoire de la Barrière Hémato-Encéphalique (LBHE), University of Artois, EA 2465, F62300 Lens, France

7. Department of Anatomy and Neurobiology, University of California, Irvine, California 92617, United States

8. Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genova, Italy

9. Endocannabinoid Research Group, Department of Experimental Medicine, Division of Pharmacology “L. Donatelli”, Second University of Napoli, 80138 Napoli, Italy

10. Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, 80078 Pozzuoli (Napoli), Italy

11. Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 16132 Genova, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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