Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies-Reference-Cited by-同舟云学术

Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies

Published:2016-01-12 Issue:9 Volume:59 Page:4245-4256
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gaspari Roberto¹,Rechlin Chris²,Heine Andreas²,Bottegoni Giovanni¹,Rocchia Walter¹,Schwarz Daniel³,Bomke Jörg³,Gerber Hans-Dieter²,Klebe Gerhard²,Cavalli Andrea¹⁴

Affiliation:

1. Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, 16163 Genova, Italy

2. Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany

3. Small Molecule Platform/MIB, Merck KGaA, Merck Serono Research, Frankfurter Str. 250, 64293 Darmstadt, Germany

4. Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy

Funder

European Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01643

Reference70 articles.

1. Carbonic Anhydrase: New Insights for an Ancient Enzyme

2. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

3. Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

4. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

5. Carbonic anhydrases as targets for medicinal chemistry

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