Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors

Author:

Soldi Raffaella1,Horrigan Stephen K.2,Cholody Marek W.3,Padia Janak4,Sorna Venkataswamy1,Bearss Jared1,Gilcrease Glynn1,Bhalla Kapil5,Verma Anupam6,Vankayalapati Hariprasad1,Sharma Sunil1

Affiliation:

1. Division of Oncology of School of Medicine and Center for Investigational Therapeutics at Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, United States

2. Beta Cat Pharmaceuticals LLC, 22 Firstfield Road, Gaithersburg, Maryland 20878, United States

3. Park Life Science, Selvita S.A., 30-348 Krakow, Poland

4. PrimeTime Life Sciences, 9700, Great Seneca Highway, Rockville, Maryland 20850, United States

5. Cockrell Center for Advanced Therapeutics, The Methodist Hospital Research Institute, 6670 Bertner Avenue, R9-113, Houston, Texas 77030, United States

6. Department of Pediatric Hematology/Oncology, Primary Children’s Hospital, University of Utah, 100 Mario Capecchi Drive, Salt Lake City, Utah 84113, United States

Funder

National Science Foundation

U.S. Department of Health and Human Services

Villum Fonden

University of Connecticut

Seventh Framework Programme

Ministerio de Economia y Competitividad

Innovation Fund Denmark

Beta Cat Pharmaceuticals LLC

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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