Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor-Reference-Cited by-同舟云学术

Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor

Published:2016-02-03 Issue:5 Volume:59 Page:1891-1898
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dousson Cyril¹,Alexandre François-René¹,Amador Agnès¹,Bonaric Séverine¹,Bot Stéphanie¹,Caillet Catherine¹,Convard Thierry¹,da Costa Daniel¹,Lioure Marie-Pierre¹,Roland Arlène¹,Rosinovsky Elodie¹,Maldonado Sébastien¹,Parsy Christophe¹,Trochet Christophe¹,Storer Richard¹,Stewart Alistair²,Wang Jingyang²,Mayes Benjamin A.²,Musiu Chiara²,Poddesu Barbara²,Vargiu Luana²,Liuzzi Michel²,Moussa Adel²,Jakubik Jocelyn²,Hubbard Luke²,Seifer Maria²,Standring David²

Affiliation:

1. IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Cedex 4 Montpellier, France

2. IDENIX, 320 Bent Street, 4th Floor, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01430

Reference23 articles.

1. Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

2. Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase