Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19-Reference-Cited by-同舟云学术

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Published:2016-01-21 Issue:3 Volume:59 Page:1078-1101
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mallinger Aurélie¹,Schiemann Kai²,Rink Christian¹,Stieber Frank²,Calderini Michel²,Crumpler Simon¹,Stubbs Mark¹,Adeniji-Popoola Olajumoke¹,Poeschke Oliver²,Busch Michael²,Czodrowski Paul²,Musil Djordje²,Schwarz Daniel²,Ortiz-Ruiz Maria-Jesus¹,Schneider Richard²,Thai Ching¹,Valenti Melanie¹,de Haven Brandon Alexis¹,Burke Rosemary¹,Workman Paul¹,Dale Trevor³,Wienke Dirk²,Clarke Paul A.¹,Esdar Christina²,Raynaud Florence I.¹,Eccles Suzanne A.¹,Rohdich Felix²,Blagg Julian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London, SW7 3RP, U.K.

2. Merck KGaA, Darmstadt, 64293, Germany

3. School of Bioscience, Cardiff University, Cardiff, CF10 3AX, U.K.

Funder

Cancer Research UK

Royal Marsden NHS Foundation Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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