Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase

Author:

Sugawara Akihiro1,Maita Nobuo2,Gouda Hiroaki3,Yamamoto Tsuyoshi1,Hirose Tomoyasu1,Kimura Saori1,Saito Yoshifumi1,Nakano Hayato1,Kasai Takako1,Nakano Hirofumi1,Shiomi Kazuro1,Hirono Shuichi3,Watanabe Takeshi4,Taniguchi Hisaaki2,O̅mura Satoshi1,Sunazuka Toshiaki1

Affiliation:

1. The Kitasato Institute, Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan

2. Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramotocho, Tokushima City, Tokushima, 770-8503, Japan

3. School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan

4. Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, 8050 Ikarashi-2, Niigata 950-2181, Japan

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

KAKENHI

Institute for Enzyme Research, The University of Tokushima

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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