Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach-Reference-Cited by-同舟云学术

Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

Published:2016-04-07 Issue:8 Volume:59 Page:3671-3688
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Innocenti Paolo¹,Woodward Hannah L.¹,Solanki Savade¹,Naud Sébastien¹,Westwood Isaac M.¹,Cronin Nora,Hayes Angela¹,Roberts Jennie¹,Henley Alan T.¹,Baker Ross¹,Faisal Amir¹,Mak Grace Wing-Yan¹,Box Gary¹,Valenti Melanie¹,De Haven Brandon Alexis¹,O’Fee Lisa¹,Saville Harry¹,Schmitt Jessica¹,Matijssen Berry¹,Burke Rosemary¹,van Montfort Rob L. M.¹,Raynaud Florence I.¹,Eccles Suzanne A.¹,Linardopoulos Spiros¹,Blagg Julian¹,Hoelder Swen¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, United Kingdom

Funder

Breakthrough Breast Cancer

Cancer Research UK

National Health Service

Cancer Research Technology Pioneer Fund

Sixth Element Capital LLP

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01811