Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases-Reference-Cited by-同舟云学术

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Published:2015-10-28 Issue:21 Volume:58 Page:8513-8528
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ruggeri Roger B.¹,Buckbinder Leonard¹,Bagley Scott W.¹,Carpino Philip A.¹,Conn Edward L.¹,Dowling Matthew S.¹,Fernando Dilinie P.¹,Jiao Wenhua¹,Kung Daniel W.¹,Orr Suvi T. M.¹,Qi Yingmei¹,Rocke Benjamin N.¹,Smith Aaron¹,Warmus Joseph S.¹,Zhang Yan¹,Bowles Daniel¹,Widlicka Daniel W.¹,Eng Heather¹,Ryder Tim¹,Sharma Raman¹,Wolford Angela¹,Okerberg Carlin¹,Walters Karen¹,Maurer Tristan S.¹,Zhang Yanwei¹,Bonin Paul D.¹,Spath Samantha N.¹,Xing Gang¹,Hepworth David¹,Ahn Kay¹,Kalgutkar Amit S.¹

Affiliation:

1. Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00963

Reference63 articles.

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