Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival-Reference-Cited by-同舟云学术

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Published:2016-02-16 Issue:6 Volume:59 Page:2346-2361
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kettle Jason G.¹,Alwan Husam¹,Bista Michal²,Breed Jason³,Davies Nichola L.²,Eckersley Kay⁴,Fillery Shaun²,Foote Kevin M.²,Goodwin Louise¹,Jones David R.¹,Käck Helena⁵,Lau Alan¹,Nissink J. Willem M.²,Read Jon³,Scott James S.²,Taylor Ben³,Walker Graeme⁴,Wissler Lisa⁵,Wylot Marta²

Affiliation:

1. Oncology Innovative Medicines Unit, AstraZeneca, 35S47 Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

2. Oncology Innovative Medicines Unit, AstraZeneca, Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom

3. Discovery Sciences, AstraZeneca, Unit 310, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom

4. Discovery Sciences, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

5. Discovery Sciences, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01760

Reference22 articles.

1. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

2. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

3. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

4. Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

5. Modes of action of TLR7 agonists in cancer therapy

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