Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists-Reference-Cited by-同舟云学术

Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists

Published:2015-10-01 Issue:20 Volume:58 Page:8236-8256
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Taylor Simon J.¹,Demont Emmanuel H.¹,Gray James¹,Deeks Nigel¹,Patel Aarti²,Nguyen Dung³,Taylor Maxine²,Hood Steve²,Watson Robert J.¹,Bit Rino A.¹,McClure Fiona⁴,Ashall Holly⁴,Witherington Jason¹

Affiliation:

1. Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

2. PTS DMPK, GlaxoSmithKline, Park Road, Ware, SG12 0DP, U.K.

3. PTS DMPK, GlaxoSmithKline, Upper Merion, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

4. Safety Assessment, GlaxoSmithKline, Park Road, Ware, SG12 0DP, U.K.

Funder

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01102

Reference40 articles.

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2. The pleiotropy of dioxin toxicity — Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

3. Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor

4. Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran

5. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

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