Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors

Published:2015-05-06 Issue:10 Volume:58 Page:4309-4324
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boland Sandro¹,Bourin Arnaud¹,Alen Jo¹,Geraets Jacques¹,Schroeders Pieter¹,Castermans Karolien¹,Kindt Nele¹,Boumans Nicki¹,Panitti Laura¹,Fransen Silke¹,Vanormelingen Jessica¹,Stassen Jean Marie¹,Leysen Dirk²,Defert Olivier¹

Affiliation:

1. Amakem Therapeutics, Agoralaan Abis, 3590 Diepenbeek, Belgium

2. CSD Farmakem, Elvire Boelensstraat 7, 9160 Lokeren, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00308

Reference37 articles.

1. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

2. ROCKs: multifunctional kinases in cell behaviour

3. Rho Kinase (ROCK) Inhibitors

4. Targeting RhoA/ROCK pathway in pulmonary arterial hypertension

5. Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

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