Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates-Reference-Cited by-同舟云学术

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Published:2016-03-22 Issue:7 Volume:59 Page:3231-3248
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mandal Mihirbaran¹,Wu Yusheng¹,Misiaszek Jeffrey¹,Li Guoqing¹,Buevich Alexei¹,Caldwell John P.¹,Liu Xiaoxiang¹,Mazzola Robert D.¹,Orth Peter¹,Strickland Corey¹,Voigt Johannes¹,Wang Hongwu¹,Zhu Zhaoning¹,Chen Xia¹,Grzelak Michael¹,Hyde Lynn A.¹,Kuvelkar Reshma¹,Leach Prescott T.¹,Terracina Giuseppe¹,Zhang Lili¹,Zhang Qi¹,Michener Maria S.¹,Smith Brad¹,Cox Kathleen¹,Grotz Diane¹,Favreau Leonard¹,Mitra Kaushik¹,Kazakevich Irina¹,McKittrick Brian A.¹,Greenlee William¹,Kennedy Matthew E.¹,Parker Eric M.¹,Cumming Jared N.¹,Stamford Andrew W.¹

Affiliation:

1. Department of Global Chemistry, ‡Department of Neuroscience, §Department of Safety Assessment and Laboratory Animal Research, ∥Department of Discovery Pharmaceutical Sciences, and ⊥Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Funder

Basic Energy Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01995

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