Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties-Reference-Cited by-同舟云学术

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Published:2016-02-08 Issue:5 Volume:59 Page:2041-2053
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hofmans Sam¹,Berghe Tom Vanden²,Devisscher Lars¹,Hassannia Behrouz²,Lyssens Sophie¹,Joossens Jurgen¹,Van Der Veken Pieter¹,Vandenabeele Peter²,Augustyns Koen¹

Affiliation:

1. Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

2. Molecular Signaling and Cell Death unit, VIB Inflammation Research Center, 9052 Ghent, Belgium

Funder

Vlaams Instituut voor Biotechnologie

Federaal Wetenschapsbeleid

Fonds Wetenschappelijk Onderzoek

Stichting Tegen Kanker

Bijzonder Onderzoeksfonds

Gentse onderzoekers over ongevouwen eiwitten in inflammatoire aandoeningen, Universiteit Gent

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01641

Reference14 articles.

1. Molecular mechanisms of necroptosis: an ordered cellular explosion

2. Regulated necrosis: the expanding network of non-apoptotic cell death pathways

3. The role of iron and reactive oxygen species in cell death

4. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

5. Synchronized renal tubular cell death involves ferroptosis

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